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Showing 1–6 of 6 results
Advanced filters: Author: "Joseph G. Gleeson" Clear advanced filters

  • Hydrocephalus describes an expansion of the cerebral ventricles that is associated with decreased cerebral volume and compromised neurological function. Although hydrocephalus mostly occurs sporadically, it is frequently associated with diseases caused by defective cilia function, including Bardet–Biedl syndrome (BBS). A new study reveals that hydrocephalus in a mouse model of BBS is related to defective proliferation and apoptosis of neural progenitor cells (NPCs) and can be rescued with lithium treatment (pages 1797–1804).

    • Bethany N Sotak
    • Joseph G Gleeson
    News & Views
    Nature Medicine
    Volume: 18, P: 1742-1743

  • Mental retardation and epilepsy can result from the aberrant migration of neurons during development. An experimental treatment in prenatal mice restores normal patterns of migration and eases symptoms (pages 84–90).

    • Geraldine Kerjan
    • Joseph G Gleeson
    News & Views
    Nature Medicine
    Volume: 15, P: 17-18

  • Recent models studying loss of the mouse homolog of the autism-associated gene CHD8 show altered Wnt signaling, cell fate and proliferation. How do these findings shape our understanding of this disease?

    • Martin W Breuss
    • Joseph G Gleeson
    News & Views
    Nature Neuroscience
    Volume: 19, P: 1430-1432

  • Aurora A, an integral mitotic kinase, is essential for microtubule dynamics of post-mitotic neurons. PKCζ activates Aurora A, which in turn phosphorylates NDEL1 to promote neurite extension. This raises the possibility that Aurora A may also be involved in establishing cell polarity and axon/dendrite elaboration in young neurons.

    • Gloria Kuo Lefkowitz
    • Joseph G. Gleeson
    News & Views
    Nature Cell Biology
    Volume: 11, P: 1053-1054

  • Primary cilia are hair-like, non-motile sensory organelles that are found on the surface of almost all cells in vertebrates. Defects in these organelles can lead to a wide array of disorders known as ciliopathies. In this Review, Valente et al. focus on ciliopathies with major neurological involvement, describing their clinical features and known pathogenetic mechanisms, and discussing the possible aetiologies of associated brain malformations.

    • Enza Maria Valente
    • Rasim O. Rosti
    • Joseph G. Gleeson
    Reviews
    Nature Reviews Neurology
    Volume: 10, P: 27-36