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Showing 1–16 of 16 results
Advanced filters: Author: "Juan Carlos Izpisua Belmonte" Clear advanced filters

  • Four leading researchers contribute their personal opinions on recent progress and current challenges in induced pluripotent stem cell research. Their varied perspectives suggest that for clinical applications there is cause for optimism, tempered with caution, and they highlight exciting recent advances in reprogramming and differentiation.

    • Juan Carlos Izpisúa Belmonte
    • James Ellis
    • Shinya Yamanaka
    Reviews
    Nature Reviews Genetics
    Volume: 10, P: 878-883

  • Pluripotent stem cells, which give rise to almost all cell types, can be engineered from mature cells. A thorough analysis of the process has led to the characterization of a new type of pluripotent cell. See Articles p.192 & p.198

    • Jun Wu
    • Juan Carlos Izpisua Belmonte
    News & Views
    Nature
    Volume: 516, P: 172-173

  • The number of conferences on epigenetics has been increasing in the past decade, underscoring the impact of the field on a variety of areas in biology and medicine. However, the mechanistic role of the epigenome in adaptation and inheritance, and how the environment may impinge on epigenetic control, are topics of growing debate. Those themes were the focus of the inaugural international King Abdullah University of Science and Technology (KAUST) Research Conference on Environmental Epigenetics in Saudi Arabia, where more than 100 participants from 19 countries enjoyed vibrant scientific discussions and a pleasant February breeze from the Red Sea.

    • Mo Li
    • Emiliana Borrelli
    • Valerio Orlando
    News & Views
    Nature Structural & Molecular Biology
    Volume: 24, P: 491-493

  • Dedifferentiation, transdifferentiation and reprogramming could all be exploited to replace lost cells and tissues. Studies are aiming to understand the molecular details of these processes and to elucidate the advantages of one process over another for use in regenerative medicine.

    • Chris Jopling
    • Stephanie Boue
    • Juan Carlos Izpisua Belmonte
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 12, P: 79-89

  • There are now myriad variations on techniques to reprogramme somatic cells into pluripotent stem cells, but which options should researchers choose? This Review sets out the choices, focusing on how the desired downstream application should guide the reprogramming strategy.

    • Federico González
    • Stéphanie Boué
    • Juan Carlos Izpisúa Belmonte
    Reviews
    Nature Reviews Genetics
    Volume: 12, P: 231-242

  • Induced pluripotent stem (iPS) cells offer the possibility to generate patient-specific cell types for use in regenerative medicine. However, a long-lasting question remains: are iPS and embryonic stem cells equivalent? iPS cells retain a transcriptional memory of their origin, which is now shown to endure with passages and to correlate with defects in the re-establishment of DNA methylation. Both selective pressure and genomic environment may account for these defects.

    • Maria J. Barrero
    • Juan Carlos Izpisua Belmonte
    News & Views
    Nature Cell Biology
    Volume: 13, P: 523-525

  • How left–right asymmetries are established in vertebrate embryos has fascinated developmental biologists for decades. Recent evidence from a range of species provides insights into the genetic and epigenetic mechanisms that are involved, particularly in the early stages of generating left–right asymmetry.

    • Ángel Raya
    • Juan Carlos Izpisúa Belmonte
    Reviews
    Nature Reviews Genetics
    Volume: 7, P: 283-293

  • Spatiotemporally distinct pluripotent states captured in vitro provide an accessible way of modelling early human development. An intricate interplay between the metabolome and histone modifications is now shown to drive the metabolic switch from human naive to primed pluripotency, one of the earliest steps of embryogenesis.

    • Jun Wu
    • Juan Carlos Izpisua Belmonte
    News & Views
    Nature Cell Biology
    Volume: 17, P: 1519-1521

  • Cellular reprogramming to a stem-cell-like state is inefficient and poorly understood, despite its biomedical potential. Detailed molecular analyses of this process are now reported, and should help to overcome these limitations.

    • Ignacio Sancho-Martinez
    • Juan Carlos Izpisua Belmonte
    News & Views
    Nature
    Volume: 493, P: 310-311

  • In advanced age, the stem cells responsible for muscle regeneration switch from reversible quiescence to irreversible senescence. Targeting a driver of senescence revives muscle stem cells and restores regeneration. See Article p.316

    • Mo Li
    • Juan Carlos Izpisua Belmonte
    News & Views
    Nature
    Volume: 506, P: 304-305

  • Embryonic stem (ES) cells and induced pluripotent stem (iPS) cells use a complex network of genetic and epigenetic pathways to maintain a delicate balance between self-renewal and multilineage differentiation. Studies using high-throughput genomic tools suggest that there is extensive crosstalk among epigenetic pathways that function at the level of DNA, histone and nucleosome. Mapping of higher-order chromatin structures and chromatin–nuclear matrix interactions provides insights into the three-dimensional organization of the genome and can reveal new rules of gene regulation.

    • Mo Li
    • Guang-Hui Liu
    • Juan Carlos Izpisua Belmonte
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 13, P: 524-535

  • Cellular fate is determined by transcriptional networks and epigenetic states. In addition to protein factors, noncoding RNAs (ncRNAs), particularly microRNAs and long ncRNAs, are able to remodel transcriptional circuits and reshape epigenetic landscapes. This Commentary highlights the emerging roles of these ncRNAs in cellular reprogramming, transdifferentiation and organ regeneration.

    • Mo Li
    • Juan Carlos Izpisua Belmonte
    Comments & Opinion
    Nature Structural & Molecular Biology
    Volume: 22, P: 2-4

  • In this article, the authors review the mechanisms by which the pluripotency gene regulatory network governs the acquisition, maintenance and dissolution of the pluripotent state, including the interaction of these networks with chromatin-mediated and RNA-mediated regulatory mechanisms. They discuss recent evidence for alternative pluripotency states and the factors that affect transitions between these states.

    • Mo Li
    • Juan Carlos Izpisua Belmonte
    Reviews
    Nature Reviews Genetics
    Volume: 18, P: 180-191