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Showing 1–4 of 4 results
Advanced filters: Author: "Jukka Corander" Clear advanced filters

  • Enterococcus faecalis is a commensal microorganism of animals, insects and humans, but also a nosocomial pathogen. Here, the authors analyse genomic sequences from E. faecalis isolates from animals and humans, and find that the last common ancestors of multiple hospital-associated lineages date to the pre-antibiotic era.

    • Anna K. Pöntinen
    • Janetta Top
    • Jukka Corander
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Little is known about the distribution, evolution and functions of the K1 capsule at a population level, despite the important role in the pathogenesis of E. coli; authors explore this through the utilisation of over 5,000 clinical isolates in population genomics studies and statistical modelling.

    • Sergio Arredondo-Alonso
    • George Blundell-Hunter
    • Alex J. McCarthy
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Opportunistic bacterial pathogen species frequently colonise the human gut as a normal part of the ecosystem but strain-level colonisation and competition dynamics in healthy hosts is yet to be established. Authors seek to understand the relationship between colonisation potential and ecological factors modulating pathogen prevalence in disease in a longitudinal cohort.

    • Tommi Mäklin
    • Harry A. Thorpe
    • Jukka Corander
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Plasticity and clonal population structure in bacterial genomes can hinder traditional SNP-based genetic association studies. Here, Corander and colleagues present a method to identify variable-length sequence elements enriched in a phenotype of interest, and demonstrate its use in human pathogens.

    • John A. Lees
    • Minna Vehkala
    • Jukka Corander
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-8