Plasmodium falciparum, the malaria parasite, relies on post-translational modifications of proteins to regulate several fundamental aspects of its life cycle and pathogenesis. Here, Doerig and colleagues focus on the roles of protein phosphorylation, acetylation, methylation and lipidation inP. falciparumbiology, and they discuss how the enzymes that mediate these modifications can be targeted by novel antimalarial drugs.
- Christian Doerig
- Julian C. Rayner
- Andrew B. Tobin