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Showing 1–7 of 7 results
Advanced filters: Author: "Julien Sage" Clear advanced filters

  • While human embryonic stem cells (ESC) hold great therapeutic promise, many aspects of their basic biology remain poorly understood. Conklin et al.show that too much or too little activation of RB family proteins is detrimental to human ESC populations and identify unique cell cycle regulatory networks in these cells.

    • Jamie F. Conklin
    • Julie Baker
    • Julien Sage
    Research
    Nature Communications
    Volume: 3, P: 1-12

  • Genomic analyses of tumours of the childhood cancer retinoblastoma reveal a low mutation rate, challenging the view that genomic instability is crucial for its progression. The work also identifies a new therapeutic target. See Article p.329

    • Julien Sage
    • Michael L. Cleary
    News & Views
    Nature
    Volume: 481, P: 269-270

  • The cellular origins of most human cancers remain unknown, but an analysis of embryonic retinal cells identifies differentiating cones as the cell of origin for the childhood cancer retinoblastoma. See Letter p.385

    • Rod Bremner
    • Julien Sage
    News & Views
    Nature
    Volume: 514, P: 313

  • G1 cyclins are considered essential for DNA replication and cell division. A recent report now shows that some cells can cycle in the absence of G1 cyclins. In embryonic stem cells and cancer cells, G1 cyclins are required to activate cyclin-dependent kinases to phosphorylate core pluripotency factors and maintain pluripotency.

    • Julia Arand
    • Julien Sage
    News & Views
    Nature Cell Biology
    Volume: 19, P: 149-150

  • Data from human and mouse tumours indicate that loss of the tumour suppressor gene retinoblastoma (RB) contributes to both cancer initiation and progression. However, there is much we still need to learn about RB function and the consequences of its loss.

    • Deborah L. Burkhart
    • Julien Sage
    Reviews
    Nature Reviews Cancer
    Volume: 8, P: 671-682