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Showing 1–3 of 3 results
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  • The role of IL-2 signalling in the transition of T cells from effector to memory cells is not well defined. Here, the authors show that T-cell receptor interactions with cognate antigen elicit IL-2 secretion from effector cells, which rescues cells from apoptosis and upregulates IL-7 receptor expression, supporting CD4 T-cell memory formation.

    • K. Kai McKinstry
    • Tara M. Strutt
    • Susan L. Swain
    Research
    Nature Communications
    Volume: 5, P: 1-12

  • Innate immune responses markedly affect subsequent adaptive responses. Here the authors show that adaptive immunity in the form of memory CD4+ T cells can also affect the magnitude of innate inflammatory responses.

    • Tara M Strutt
    • K Kai McKinstry
    • Susan L Swain
    Research
    Nature Medicine
    Volume: 16, P: 558-564

  • Immunity to viruses is typically associated with the development of cytotoxic CD8+ T cells. However, CD4+ T cells are also important for protection during viral infection. Here, the authors describe the various ways in which different CD4+T cell subsets can contribute to the antiviral immune response.

    • Susan L. Swain
    • K. Kai McKinstry
    • Tara M. Strutt
    Reviews
    Nature Reviews Immunology
    Volume: 12, P: 136-148