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Showing 1–2 of 2 results
Advanced filters: Author: "K Kataoka" Clear advanced filters

  • Controlling blood circulation, biodistribution and tissue accessibility of nanomedicines is key to their clinical translation. In this Review, bioengineering strategies to overcome gatekeeping barriers and promote the targeting, safety and efficacy of nanomedicines are discussed.

    • Horacio Cabral
    • Junjie Li
    • Kazunori Kataoka
    Reviews
    Nature Reviews Bioengineering
    Volume: 2, P: 214-232

  • This review focuses on the physicochemical characterization of polyion complex (PIC) micelles, particularly addressing the critical molecular factors to determine the self-assembly scheme of double-hydrophilic block copolymers composed of charged and non-charged segments into micelle structures. The process of PIC micelle formation provides new insights on the block copolymer self-assembly in thermodynamically equilibrium condition in aqueous medium, such as chain length recognition and transition from uPIC, which is the PIC of smallest neutralizing unit, to PIC micelle structures.

    • Atsushi Harada
    • Kazunori Kataoka
    Reviews
    Polymer Journal
    Volume: 50, P: 95-100