There is mounting evidence of the involvement of the glutamatergic system in mood-disorder pathophysiology as well as of the efficacy of glutamatergic agents in mood disorders. In this Review, the authors examine the contribution of abnormalities in the glutamatergic system to the impairments in neural plasticity that are observed in patients with mood disorders, and how this knowledge can be applied to the development of antidepressants with more rapid and sustained effects.
- Gerard Sanacora
- Carlos A. Zarate
- Husseini K. Manji
