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Showing 1–4 of 4 results
Advanced filters: Author: "K. Choi" Clear advanced filters

  • The inflammasome has been linked to metabolic disorders such as obesity and type 2 diabetes. Data now suggest that the crosstalk between the inflammasome and autophagy critically mediates cytoplasmic receptor NLRP3–dependent activation of the inflammasome by the saturated fatty acids contained in a high-fat diet.

    • Augustine M K Choi
    • Kiichi Nakahira
    News & Views
    Nature Immunology
    Volume: 12, P: 379-380

  • In this Consensus Statement, an expert panel compares and contrasts recommendations for the management of gout produced by rheumatology organizations and the American College of Physicians (ACP), and present the G-CAN position on the ACP guideline.

    • Nicola Dalbeth
    • Thomas Bardin
    • Robert Terkeltaub
    ReviewsOpen Access
    Nature Reviews Rheumatology
    Volume: 13, P: 561-568

  • Mendelian randomization analysis makes use of random inheritance of genetic variants to limit confounding in tests for causal relationships between risk factors and disease outcomes. This Review considers the current and future applications, as well as the limitations, of Mendelian randomization in rheumatology.

    • Philip C. Robinson
    • Hyon K. Choi
    • Tony R. Merriman
    Reviews
    Nature Reviews Rheumatology
    Volume: 12, P: 486-496

  • The validity of research into risk factors for the development of rheumatic conditions and their sequelae can be threatened by selection bias. In this Review, the authors outline potentially major selection bias issues in rheumatic disease research and suggest approaches which could be used to help limit the impact of these biases on future research.

    • Hyon K. Choi
    • Uyen-Sa Nguyen
    • Yuqing Zhang
    Reviews
    Nature Reviews Rheumatology
    Volume: 10, P: 403-412