Sepsis-associated encephalopathy (SAE) is a severe neurological consequence of sepsis that carries a high risk of mortality. Although the signs and symptoms of SAE are well-recognized, the underlying pathomechanisms of sepsis-associated neurological dysfunction are poorly understood. In this Review, Stubbs et al. discuss how imaging can provide insight into the pathophysiology of SAE, outlining current approaches to diagnostic imaging in research and clinical studies, and highlighting how 'next-generation' imaging technologies might improve understanding, diagnosis and management of SAE.
- Daniel J. Stubbs
- Adam K. Yamamoto
- David K. Menon
