Diblock functional poly(ɛ-caprolactone)s (PαN3CL-g-BioM)-b-PCLs grafted with bioactive molecules were performed by Huisgen’s 1,3-dipolar cycloaddition. These amphiphilic copolymers can self-assemble into micelles in the aqueous medium with critical micelle concentration (CMC) in the range 4.6–20 mg l−1, and the average micelle size ranged from 105 to 162 nm. In vitro cell viability assays showed that (PαN3CL-g-BioM)-b-PCL has low cytotoxicity.
- Yi-Ting Huang
- Kang-Yu Peng
- Ren-Shen Lee