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Showing 1–7 of 7 results
Advanced filters: Author: "Karen Adelman" Clear advanced filters

  • Gene expression dynamics are tightly regulated during spermatogenesis, with disruptions resulting in infertility. Here they identify a critical role for RNA PolII pausing in spermatogenesis and show that loss of the RNA PolII pausing factor NELF causes meiotic arrest.

    • Emily G. Kaye
    • Kavyashree Basavaraju
    • Prabhakara P. Reddi
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • The enzyme RNA polymerase II, which transcribes DNA, pauses early in transcription and awaits signals to continue. High-resolution structures reveal how it is stopped and efficiently restarted.

    • Karen Adelman
    • Telmo Henriques
    News & Views
    Nature
    Volume: 560, P: 560-561

  • It emerges that nascent non-coding RNAs transcribed from regulatory DNA sequences called enhancers bind to the enzyme CBP to promote its activity locally. In turn, the activities of CBP stimulate further enhancer transcription.

    • Karen Adelman
    • Emily Egan
    News & Views
    Nature
    Volume: 543, P: 183-185

  • The mechanisms underlying specific TSS selection in mammals remain unclear. Here the authors show that the ubiquitously expressed transcription factor NF-Y regulate fidelity of transcription initiation at gene promoters, maintaining the region upstream of TSSs in a nucleosome-depleted state, while protecting this region from ectopic transcription initiation.

    • Andrew J. Oldfield
    • Telmo Henriques
    • Raja Jothi
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • A new study demonstrates that profiles of nascent RNA accurately predict genomic patterns of histone modifications and chromatin state. Consistent with that, active histone marks are revealed to reflect transcription activity, rather than preceding or directing gene output.

    • Karen Adelman
    News & Views
    Nature Genetics
    Volume: 54, P: 223-224

  • Emerging evidence points towards RNA polymerase II promoter-proximal pausing as a widespread regulatory mechanism in higher eukaryotes. Here, the authors discuss the evidence for this from genome-wide studies and present potential functions of this regulatory mechanism.

    • Karen Adelman
    • John T. Lis
    Reviews
    Nature Reviews Genetics
    Volume: 13, P: 720-731

  • Here the authors present the INSERT-seq methodology to investigate the effect of transcribed sequence on processive transcription. The authors find that GC content and splice site sequences are important determinants of elongation potential.

    • Hanneke Vlaming
    • Claudia A. Mimoso
    • Karen Adelman
    Research
    Nature Structural & Molecular Biology
    Volume: 29, P: 613-620