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Showing 1–2 of 2 results
Advanced filters: Author: "Karl Skorecki" Clear advanced filters

  • Population-based genetic studies initially identifiedMYH9as a major susceptibility locus for diabetes-unrelated kidney diseases in persons of West African ancestry, but further research found more strongly associated mutations in the neighboring APOL1 gene. This Review describes how evolutionary selection pressure of an infectious pathogen in West Africa favored the spread of APOL1 variants that protect against a lethal form of African sleeping sickness but are associated with an increased risk of kidney disease. The authors discuss lessons that can be learned for future population genetics research.

    • Saharon Rosset
    • Shay Tzur
    • Karl Skorecki
    Reviews
    Nature Reviews Nephrology
    Volume: 7, P: 313-326

  • Chronic kidney disease (CKD) is often clinically silent and traditional clinical data alone cannot differentiate disease subtypes. A recent study of the genetic basis of CKD in adults that examined the prevalence of monogenic kidney disease aetiologies supports the use of genetic analysis to improve diagnostics and treatment in CKD.

    • Asaf Vivante
    • Karl Skorecki
    News & Views
    Nature Reviews Nephrology
    Volume: 15, P: 321-322