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Showing 1–8 of 8 results
Advanced filters: Author: "Katherine A. Fitzgerald" Clear advanced filters

  • Many pathogens induce a type I interferon response via a pathway dependent on the kinase TBK1 and transcription factor IRF3. However, LRRFIP1, a cytosolic sensor of DNA and RNA, triggers interferon production by a β-catenin-dependent signal.

    • Vijay A K Rathinam
    • Shruti Sharma
    • Katherine A Fitzgerald
    News & Views
    Nature Immunology
    Volume: 11, P: 466-468

  • Guanylate-binding proteins (GBPs) induced by type I interferon signaling cause lysis of Francisella bacteria that have reached the host-cell cytosol. The liberated bacterial DNA is then sensed by the cytosolic AIM2 inflammasome, which activates caspase-1 and leads to pyroptotic cell death.

    • Katherine A Fitzgerald
    • Vijay A K Rathinam
    News & Views
    Nature Immunology
    Volume: 16, P: 443-444

  • In this Review, the authors highlight the importance of the diverse mechanisms that regulate the expression of innate immune genes post transcription. These regulatory mechanisms act at the level of mRNA splicing, mRNA polyadenylation, mRNA stability and protein translation, and they are important for controlling the magnitude and duration of inflammatory responses.

    • Susan Carpenter
    • Emiliano P. Ricci
    • Katherine A. Fitzgerald
    Reviews
    Nature Reviews Immunology
    Volume: 14, P: 361-376

  • Host-cell detection of lipopolysaccharide in the outer membrane of Gram-negative bacteria was thought to be restricted to the cell-surface receptor TLR4. It emerges that lipopolysaccharide can also be sensed in the cytoplasm.

    • Vijay A. K. Rathinam
    • Katherine A. Fitzgerald
    News & Views
    Nature
    Volume: 501, P: 173-175

  • Here the authors describe how multiple pattern recognition receptors, at the host cell surface, in endosomes and in the cytoplasm, are involved in detecting herpesviruses. How do they each contribute to immune defence against the virus, and how does the virus evade this detection and persist in the host?

    • Søren R. Paludan
    • Andrew G. Bowie
    • Katherine A. Fitzgerald
    Reviews
    Nature Reviews Immunology
    Volume: 11, P: 143-154

  • Malaria infections can result in deleterious activation of innate immune cells. In this Review, the authors summarize how thePlasmodiumparasite is recognized by innate immune receptors, and discuss the role of these receptors in host resistance to infection and in the pathogenesis of malaria.

    • Ricardo T. Gazzinelli
    • Parisa Kalantari
    • Douglas T. Golenbock
    Reviews
    Nature Reviews Immunology
    Volume: 14, P: 744-757

  • The mouse pathogenCitrobacter rodentium has long been used as a model for investigating the pathogenesis of the important enteric human pathogens, enterohaemorrhagic Escherichia coli (EHEC) and enteropathogenic E. coli(EPEC). In this Review, Frankel and colleagues discuss the infection cycle of this pathogen, the mucosal immune response that is elicited and the role of the gut microbiota in preventing colonization.

    • James W. Collins
    • Kristie M. Keeney
    • Gad Frankel
    Reviews
    Nature Reviews Microbiology
    Volume: 12, P: 612-623