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Showing 1–6 of 6 results
Advanced filters: Author: "Kathy Pritchard-Jones" Clear advanced filters

  • In this Viewpoint, four key opinion leaders discuss the slow rate of drug development in paediatric oncology, which must be addressed in a meaningful way if we are to make progress. They discuss a range of aspects, from clinical trial design and biomarker discovery to regulatory amendments and input from industry, government, academia, non-governmental organizations and patient advocacy groups.

    • Peter C. Adamson
    • Peter J. Houghton
    • Kathy Pritchard-Jones
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 11, P: 732-739

  • A new study provides a comprehensive catalogue of the genetic changes in Wilms tumour. Understanding the interplay between genetic and epigenetic aberrations during tumorigenesis and clonal evolution is fundamental to enabling prediction of who is at risk and which tumours will relapse when so many are curable.

    • William Mifsud
    • Kathy Pritchard-Jones
    News & Views
    Nature Reviews Urology
    Volume: 14, P: 703-704

  • Optimizing first-line therapies to reduce the risk of permanent adverse effects is increasingly important in children treated for nonmetastatic, unilateral Wilms tumour. The long-term effects of radical nephrectomy on renal function have not been well studied but new data have given some insight into the lasting outcomes of this surgery.

    • Aoife M. Waters
    • Kathy Pritchard-Jones
    News & Views
    Nature Reviews Urology
    Volume: 12, P: 423-424

  • Patients diagnosed with cancer through an emergency presentation have worse outcomes compared with those in whom cancer is diagnosed through other routes; therefore, reducing the number of patients presenting as an emergency with cancer will improve patients' outcomes. In this Review, the authors describe the available evidence in this area, and provide recommendations for future research, clinical practice and public health policy.

    • Yin Zhou
    • Gary A. Abel
    • Georgios Lyratzopoulos
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 14, P: 45-56

  • The Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP–RTSG) has developed a new protocol for the diagnosis and treatment of childhood renal tumours, the UMBRELLA SIOP–RTSG 2016 (the UMBRELLA protocol). In this Consensus Statement, members of SIOP–RTSG outline the rationale for the recommendations in the protocol.

    • Marry M. van den Heuvel-Eibrink
    • Janna A. Hol
    • Norbert Graf
    ReviewsOpen Access
    Nature Reviews Urology
    Volume: 14, P: 743-752