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Advanced filters: Author: "Kenneth J Oestreich" Clear advanced filters

  • There has been a tendency to associate the development of distinct CD4+T cell subsets with the expression of 'master regulator' transcription factors. Here, the authors discuss the shortcomings of this model and explain why 'lineage-specifying' may be a more fitting way to describe these key transcription factors.

    • Kenneth J. Oestreich
    • Amy S. Weinmann
    Reviews
    Nature Reviews Immunology
    Volume: 12, P: 799-804

  • The inclusion of the transcription factor Ikaros in the NuRD chromatin-remodeling complex regulates both the targeting and activity of the NuRD complex in lymphocytes, thereby influencing developmental gene-expression programs.

    • Kenneth J Oestreich
    • Amy S Weinmann
    News & Views
    Nature Immunology
    Volume: 13, P: 16-18