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Showing 1–7 of 7 results
Advanced filters: Author: "Kevin J Tracey" Clear advanced filters

  • Acetylcholine and related neurotransmitters appeared with unicellular life forms, millions of years before innate immunity. Tools and insights are now available for understanding how the evolving nervous system influenced the development of immunity.

    • Kevin J Tracey
    Comments & Opinion
    Nature Immunology
    Volume: 11, P: 561-564

  • Kristoffer Famm and colleagues unveil a multidisciplinary initiative to develop medicines that use electrical impulses to modulate the body's neural circuits.

    • Kristoffer Famm
    • Brian Litt
    • Moncef Slaoui
    Comments & Opinion
    Nature
    Volume: 496, P: 159-161

  • Neural circuits are able to modulate immune responses by detecting inflammatory mediators and relaying signals back to the immune system. Here, in a mouse model of sepsis, the authors show that the immune responses can be modulated by electroacupuncture, which stimulates a neural circuit that results in the release of dopamine. The mechanism, like the inflammatory reflex, is neither sympathetic nor parasympathetic. Their results show a potential way forward in developing therapies for sepsis in dopamine agonists (pages 291–295).

    • Sangeeta S Chavan
    • Kevin J Tracey
    News & Views
    Nature Medicine
    Volume: 20, P: 239-241

  • Vagus-nerve signalling regulates immune activation and metabolic homeostasis. Dysregulation of metabolism and immune function in obesity results in chronic inflammation associated with insulin resistance and type 2 diabetes mellitus. In this Review, exploiting the vagus-nerve-mediated inflammatory reflex in the treatment of obesity-related disorders is discussed.

    • Valentin A. Pavlov
    • Kevin J. Tracey
    Reviews
    Nature Reviews Endocrinology
    Volume: 8, P: 743-754

  • In this Review, Mark Okusa and colleagues discuss the role of neural circuits in the control of renal inflammation as well as the therapeutic potential of targeting these circuits in the settings of acute kidney injury, kidney fibrosis and hypertension.

    • Mark D. Okusa
    • Diane L. Rosin
    • Kevin J. Tracey
    Reviews
    Nature Reviews Nephrology
    Volume: 13, P: 669-680

  • Work in the past decade has revealed the role of neural circuits in modulating inflammatory conditions. Here, Kevin Tracey discusses the inflammatory reflex, and in particular the efferent arc of this reflex, which is known as the cholinergic anti-inflammatory pathway. In this pathway, acetylcholine activity suppresses the release of pro-inflammatory cytokines.

    • Kevin J. Tracey
    Reviews
    Nature Reviews Immunology
    Volume: 9, P: 418-428