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Showing 1–4 of 4 results
Advanced filters: Author: "Kevin M. Ryan" Clear advanced filters

  • Tumour viruses can cause cancer by altering gene expression and protein activity in the host cell. Tumour adenoviruses, however, seem to go to great lengths to ensure that one particular host cell protein, p53, is suppressed.

    • Kevin M. Ryan
    News & Views
    Nature
    Volume: 466, P: 1054-1055

  • Macroautophagy is a key regulator of cellular integrity and viability, but how the process facilitates apoptosis has remained poorly defined. It has now become clear that autophagy degrades the Fap-1 protein phosphatase, a critical negative regulator of apoptotic cell death signalled by the TNF receptor family member, Fas.

    • Sanket Joshi
    • Kevin M. Ryan
    News & Views
    Nature Cell Biology
    Volume: 16, P: 23-25

  • p53 can regulate numerous aspects of metabolic pathways and thereby influence the metabolic alterations exhibited by tumour cells. However, the contribution of p53 is complex and in some cases might promote, rather than inhibit, tumour progression. So, just what is p53 doing?

    • Karen H. Vousden
    • Kevin M. Ryan
    Reviews
    Nature Reviews Cancer
    Volume: 9, P: 691-700