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Showing 1–4 of 4 results
Advanced filters: Author: "Klaus Ley" Clear advanced filters

  • Two hallmarks of lung fibrosis are vascular leakage and recruitment of fibroblasts into the alveoli. Lysophosphatidic acid is now implicated as a major regulator of both parameters (pages 45–54).

    • Klaus Ley
    • Alexander Zarbock
    News & Views
    Nature Medicine
    Volume: 14, P: 20-21

  • To get to the site of inflammation, leukocytes must first adhere to and traverse the blood-vessel wall, events that occur in a cascade-like manner. But what are the exact steps in this cascade and what molecules are involved?

    • Klaus Ley
    • Carlo Laudanna
    • Sussan Nourshargh
    Reviews
    Nature Reviews Immunology
    Volume: 7, P: 678-689

  • Members of the integrin family of receptors, which are involved in cell–cell adhesion, have been successfully targeted for cardiovascular disease, multiple sclerosis and inflammatory bowel disease. Ley and colleagues review the biological basis for the development of the next generation of integrin-targeted drugs, highlighting lessons learned from successes and failures.

    • Klaus Ley
    • Jesus Rivera-Nieves
    • Sanford Shattil
    Reviews
    Nature Reviews Drug Discovery
    Volume: 15, P: 173-183