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Showing 1–3 of 3 results
Advanced filters: Author: "Klaus Peter Hofmann" Clear advanced filters

  • Rhodopsin is a light-activated G-protein-coupled receptor. The structure of its ligand-free state at 2.9 Å resolution was reported recently. This paper describes a similar resolution crystal structure of the same protein bound to a fragment of G-protein and suggests a mechanism by which G-proteins might be activated by G-protein-coupled receptors.

    • Patrick Scheerer
    • Jung Hee Park
    • Oliver P. Ernst
    Research
    Nature
    Volume: 455, P: 497-502

  • The crystal structure of a ligand-free opsin at 2.9 Å resolution is reported; the entrance pathway for 11-cis-retinal and the exit pathway for all-trans-retinal are apparent.

    • Jung Hee Park
    • Patrick Scheerer
    • Oliver Peter Ernst
    Research
    Nature
    Volume: 454, P: 183-187

  • Here the X-ray crystal structure of the metarhodopsin II intermediate of the photoreceptor rhodopsin is solved. Comparison of this structure with previously published structures enabled the proposal of how retinal translocation and rotation induce the conformational changes observed in this structure.

    • Hui-Woog Choe
    • Yong Ju Kim
    • Oliver P. Ernst
    Research
    Nature
    Volume: 471, P: 651-655