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Showing 1–7 of 7 results
Advanced filters: Author: "Klaus Aktories" Clear advanced filters

  • Infection by the bacterium Clostridioides difficile can be fatal in a clinical setting. Insights into the molecular mechanisms underlying such infection might offer targets for the search to develop new treatments.

    • Klaus Aktories
    News & Views
    Nature
    Volume: 622, P: 465-467

  • Many bacterial pathogens produce protein toxins and effectors that target host regulatory GTPases such as those belonging to the RHO family, which control the actin cytoskeleton. In this Review, Aktories discusses the mechanisms used by these bacterial proteins to modulate the activity of host GTPases, with a focus on covalent modifications.

    • Klaus Aktories
    Reviews
    Nature Reviews Microbiology
    Volume: 9, P: 487-498

  • A new bacterial toxin from pathogen Photorhabdus asymbiotica is now described. The toxin contains a domain with glycosyltransferase activity that modifies a tyrosine residue of Rho GTPases in the host cell, inhibiting Rho activation and interaction with downstream effectors. The second domain is a glutamine deamidase that blocks GTP hydrolysis by Gaq/11 and Gai proteins.

    • Thomas Jank
    • Xenia Bogdanović
    • Klaus Aktories
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 1273-1280

  • Bacterial ADP-ribosyltransferase toxins (bARTTs) transfer ADP-ribose to a range of eukaryotic proteins to promote bacterial pathogenesis. In this Review, the authors discuss the structural and functional properties of the most recently identified novel bARTTs, which are produced by various human, insect and plant pathogens and were identified using bioinformatic analyses.

    • Nathan C. Simon
    • Klaus Aktories
    • Joseph T. Barbieri
    Reviews
    Nature Reviews Microbiology
    Volume: 12, P: 599-611