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Showing 1–7 of 7 results
Advanced filters: Author: "Kristina Schoonjans" Clear advanced filters
  • 3D liver organoids hold great promise for regenerative medicine but the use of ill-defined matrices limits their potential. Here, the authors generate human and mouse liver organoids using a chemically defined matrix, and reveal a link between matrix stiffness and organoid growth that does not require acto-myosin contraction.

    • Giovanni Sorrentino
    • Saba Rezakhani
    • Kristina Schoonjans
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10
  • The recent awareness that bile acids act as complex metabolic integrators and signalling factors has led to the recognition of bile-acid signalling as a potential novel therapeutic target in metabolic disease. Thomas and colleagues overview the metabolic roles of bile acids and discuss approaches to modulate their signalling pathways in the treatment of disorders including obesity, type 2 diabetes, hypertriglyceridaemia and atherosclerosis.

    • Charles Thomas
    • Roberto Pellicciari
    • Kristina Schoonjans
    Reviews
    Nature Reviews Drug Discovery
    Volume: 7, P: 678-693
  • White adipose tissue can undergo a process of beiging and acquire functional characteristics similar to brown adipose tissue, including the ability to dissipate energy via uncoupled respiration. Here, Velazquez-Villegas et al. show that activation of the bile acid membrane receptor, TGR5, leads to white adipocyte beiging by promoting mitochondrial fission.

    • Laura A. Velazquez-Villegas
    • Alessia Perino
    • Kristina Schoonjans
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13
  • Bile acids are shown to enter the brain and regulate short-term reductions in food intake after a meal by inhibiting neuropeptide release from agouti-related peptide/neuropeptide Y neurons.

    • Alessia Perino
    • Laura. A. Velázquez-Villegas
    • Kristina Schoonjans
    Research
    Nature Metabolism
    Volume: 3, P: 595-603
  • Enormous differences exist between human studies, which show a strong association of low vitamin D status with obesity, and mouse data, where low vitamin D signalling causes resistance to obesity. Understanding these discrepancies may provide better insight into the spectrum of activities of vitamin D and should be of interest considering the world epidemic of obesity and the metabolic syndrome.

    • Roger Bouillon
    • Geert Carmeliet
    • Annemieke Verstuyf
    Reviews
    Nature Reviews Endocrinology
    Volume: 10, P: 79-87
  • Perino and Schoonjans summarize the most recent literature on the receptor-mediated role of bile acid signalling in the control of peripheral and central energy homeostasis.

    • Alessia Perino
    • Kristina Schoonjans
    Reviews
    Nature Metabolism
    Volume: 4, P: 416-423