C-terminal mutations in the XPB helicase subunit of TFIIH are associated with cancer. Here, using Drosophilamodels, the authors demonstrate C-terminally truncated Hay/XPB alleles enhance overgrowth dependent on Hfp, the orthologue of the MYC transcriptional repressor FIR.
- Jue Er Amanda Lee
- Naomi C. Mitchell
- Leonie M. Quinn