Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–4 of 4 results
Advanced filters: Author: "Lan Guan" Clear advanced filters
  • The bacterial symporter MelB transports galactosides with Na+, Li+ or H+ ions. Ethayathulla et al. present crystal structures of MelB in two distinct conformations, providing the first structural insights into the transport mechanism of a sodium-coupled permease of the major facilitator superfamily.

    • Abdul S. Ethayathulla
    • Mohammad S. Yousef
    • Lan Guan
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-11
  • Guan and Hariharan report two crystal structures of melibiose transporter MelB in complex with substrate analogs, nitrophenyl-galactoside, and dodecyl-melibioside. Both structures revealed similar specific site for sugar recognition and resolved the cation-binding pocket, advancing the understanding of MelB and related transporters.

    • Lan Guan
    • Parameswaran Hariharan
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-13
  • Membrane transporters are an important group of proteins in physiology and disease. Their functions make them common drug targets, but their location in the lipid bilayers poses a tremendous challenge to researchers. The current stage of development of structural biology, in addition to new research tools, has largely facilitated the acquisition of knowledge about transporters and mechanisms. This Collection presents recent studies, covering bioenergetics, structure and functional characterization of various transporters, lipids-protein interactions, and novel research tool development.

    • Lan Guan
    EditorialOpen Access
    Scientific Reports
    Volume: 12, P: 1-3