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Showing 1–8 of 8 results
Advanced filters: Author: "Lars Bertram" Clear advanced filters

  • Studies of the genetic causes of Alzheimer's disease have yielded a bewildering array of candidate genes. Bertram and Tanzi describe the results of ongoing systematic meta-analyses of these studies and discuss how some of the risk factors identified might contribute to disease pathology.

    • Lars Bertram
    • Rudolph E. Tanzi
    Reviews
    Nature Reviews Neuroscience
    Volume: 9, P: 768-778

  • A new genome-wide association study has identified 41 previously unknown loci associated with Alzheimer disease. However, these data provide limited insight into disease mechanisms or benefits for clinical prediction of Alzheimer disease.

    • Christina M. Lill
    • Lars Bertram
    News & Views
    Nature Reviews Neurology
    Volume: 18, P: 387-388

  • The risk of Alzheimer disease is substantially influenced by genetic factors. A new genome-wide association study of more than 600,000 individuals identifies nine novel Alzheimer disease risk genes, raising the total count of independent risk loci to 29.

    • Lars Bertram
    • Rudolph E. Tanzi
    News & Views
    Nature Reviews Neurology
    Volume: 15, P: 191-192

  • Many genetic mutations and several environmental factors contribute to Alzheimer's disease. Yet another disease risk gene, one that is involved in calcium regulation, has been added to the mix.

    • Rudolph E. Tanzi
    • Lars Bertram
    News & Views
    Nature
    Volume: 454, P: 707-708

  • Genome-wide association studies (GWAS) have uncovered over two dozen candidate Alzheimer disease susceptibility genes; however, the results of these studies showed limited overlap. Two independently performed GWAS involving cohorts from Europe and the US have now identified three additional putative Alzheimer disease genes that show modest but remarkably consistent effects across data sets.

    • Lars Bertram
    • Rudolph E. Tanzi
    News & Views
    Nature Reviews Neurology
    Volume: 6, P: 11-13