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Showing 1–7 of 7 results
Advanced filters: Author: "Laurie H Glimcher" Clear advanced filters

  • The transcription factor T-bet is best known to immunologists as a master regulator of T helper 1 cell differentiation. However, it is becoming apparent that T-bet has important functions in other leukocyte populations, including memory CD8+T cells, B cells, innate lymphoid cells, dendritic cells and natural killer cells. This Review discusses these emerging immunological roles for T-bet.

    • Vanja Lazarevic
    • Laurie H. Glimcher
    • Graham M. Lord
    Reviews
    Nature Reviews Immunology
    Volume: 13, P: 777-789

  • How have women fared at Harvard since the events of four years ago? Here, Judy Lieberman and Laurie Glimcher reflect on progress made and barriers still to be breached.

    • Laurie H Glimcher
    • Judy Lieberman
    Comments & Opinion
    Nature Immunology
    Volume: 10, P: 559-561

  • Discovering the transcription factors that direct lineage commitment in the T helper cell was a formidable task. Laurie Glimcher describes how she and Susanne Szabo hunted down T-bet, a transcription factor that is a 'master regulator' of commitment to the T helper type 1 lineage.

    • Laurie H Glimcher
    Comments & Opinion
    Nature Immunology
    Volume: 8, P: 448-450

  • The unfolded-protein response (UPR) protects cells from stress induced by the accumulation of unfolded proteins in the endoplasmic reticulum. As discussed here, an important role for the UPR has recently been described in the immune system, dysregulation of which could potentially contribute to autoimmunity.

    • Derrick J. Todd
    • Ann-Hwee Lee
    • Laurie H. Glimcher
    Reviews
    Nature Reviews Immunology
    Volume: 8, P: 663-674

  • This Review explores the main mechanisms of inflammation and the role of innate immune sensors in gouty arthritis, and discusses potential therapeutic approaches aimed at regulating these processes.

    • Alexander K. So
    • Fabio Martinon
    Reviews
    Nature Reviews Rheumatology
    Volume: 13, P: 639-647

  • In this Review, Martinon and Aksentijevich highlight the latest developments in research into the pathogenesis of autoinflammatory diseases. Newly discovered disease-causing mutations and molecular pathways underlying inherited autoinflammatory diseases are discussed.

    • Fabio Martinon
    • Ivona Aksentijevich
    Reviews
    Nature Reviews Rheumatology
    Volume: 11, P: 11-20