Copper-catalysed enantioconvergent radical Michaelis–Becker-type C(sp3)–P cross-coupling of diverse racemic alkyl halides with H-phosphonates has been achieved, overcoming the competing SN2 mechanism. Multidentate chiral ligands are crucial to prevent catalyst poisoning and enhance the reducing capability of the copper catalyst for initiation of the radical process.
- Li-Lei Wang
- Huan Zhou
- Xin-Yuan Liu
