Mechanical ventilation may cause diaphragm weakness due to muscle injury and atrophy. This study shows that endotoxin-augmented mechanical ventilation-induced diaphragmatic injury occurs through the activation of toll-like receptor 4 and nuclear factor-κB signaling pathways. These findings may aid in the development of treatments for patients with sepsis.
- Li-Fu Li
- Yung-Yang Liu
- Li-Chung Chiu