This study dissects the contribution of TLR signaling to intestinal tumorigenesis. MyD88 signaling, known to be required for tumorigenesis in Apcmin/+ mice, is shown to be triggered by ligands from the microflora. MyD88-mediated activation of the MEK-ERK cascade stabilizes c-Myc by preventing its ubiquitin-mediated degradation. The findings link oncogenic c-Myc function to immune signaling and uncover MEK inhibition as a new therapeutic strategy to treat intestinal tumors.
- Sung Hee Lee
- Li-Li Hu
- Eyal Raz