Reduced adiponectin levels have been shown to correlate with increased risk of cardiovascular disease in obese individuals and in patients with diabetes and hyperglycemia. In this Review, Drs Goldstein, Scalia and Ma discuss the various signaling pathways that mediate adiponectin's protective effects in the vasculature and the myocardium.
- Barry J Goldstein
- Rosario G Scalia
- Xin L Ma