Inactivation of tumor suppressor genes such asSETD2, KDM6A, KDM5C and PBRM1 has been reported in renal cell carcinoma (RCC)—notably, the proteins encoded by these genes are involved in histone and chromatin regulation. Here, Larkin et al. discuss the role of histone and chromatin regulation in RCC biology and how understanding of epigenetic mechanisms might identify novel therapeutic targets in RCC.
- James Larkin
- Xin Yi Goh
- Charles Swanton
