Cofilin severing activity can generate free actin filament ends that are accessible for F-actin polymerization and depolymerization. The combination of structural data for filament severing with recently discovered mechanisms for cofilin activation in migrating cells is increasing our understanding of how cofilin activity affects cell behaviour.
- Jose Javier Bravo-Cordero
- Marco A. O. Magalhaes
- John Condeelis