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Showing 1–11 of 11 results
Advanced filters: Author: "Ludger Johannes" Clear advanced filters

  • Gangliosides such as GM1 present in the outer leaflet of the plasma membrane of eukaryotic cells are essential for many cellular functions and pathogenic interactions. Here the authors show that the acyl chain structure of GM1 determines the establishment of nanodomains when actively clustered by actin, which depended on membrane cholesterol and phosphatidylserine or superimposed by the GM1-binding bacterial cholera toxin.

    • Senthil Arumugam
    • Stefanie Schmieder
    • Ludger Johannes
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Johannes and colleagues report that retrograde trafficking of non-liganded β1 integrin from the plasma membrane to the trans-Golgi network to then be secreted in a polarized manner is needed for cell adhesion and persistent migration.

    • Massiullah Shafaq-Zadah
    • Carina S. Gomes-Santos
    • Ludger Johannes
    Research
    Nature Cell Biology
    Volume: 18, P: 54-64

  • Many cell surface receptors are internalized by clathrin-independent endocytosis, but how clathrin-independent carriers (CLICs) are generated at the plasma membrane remained unclear. Johannes and colleagues now report that galectin-3 (Gal3) binds to glycosylated cargo proteins and glycosphingolipids. These interactions induce membrane deformation, revealing a mechanism for CLIC biogenesis.

    • Ramya Lakshminarayan
    • Christian Wunder
    • Ludger Johannes
    Research
    Nature Cell Biology
    Volume: 16, P: 592-603

  • The ER exit site component Sec16A was identified as the target of Retro-2, a small-molecule inhibitor of protein toxins and pathogens. Retro-2 treatment alters retrograde early/maturing endosomes-to-Golgi trafficking of Shiga toxin.

    • Alison Forrester
    • Stefan J. Rathjen
    • Ludger Johannes
    Research
    Nature Chemical Biology
    Volume: 16, P: 327-336

  • The retromer complex coordinates retrograde transport of cargo proteins between endosomes and the trans-Golgi network. The sorting nexin SNX3 is required for the retrograde trafficking of Wntless, but not of other retrograde cargo proteins, revealing that the cargo specificity of retromer is provided by the sorting nexins.

    • Ludger Johannes
    • Christian Wunder
    News & Views
    Nature Cell Biology
    Volume: 13, P: 884-886

  • The Shiga toxins are a family of exotoxins that are produced byShigella dysenteriae and enterohaemorrhagic strains of Escherichia coli. In this Review, Johannes and Römer summarize the structural and cellular biology of Shiga toxins, describe the role of apoptosis during intoxication and discuss how Shiga toxins might be exploited as therapeutics.

    • Ludger Johannes
    • Winfried Römer
    Reviews
    Nature Reviews Microbiology
    Volume: 8, P: 105-116

  • How endocytic pits are formed in clathrin- and caveolin-independent endocytosis remains poorly understood. However, recent insight suggests that different forms of clathrin-independent endocytosis might involve the actin-driven focusing of membrane constituents, the lectin–glycosphingolipid-dependent construction of endocytic nanoenvironments and the use of Bin–Amphiphysin–Rvs (BAR) domain proteins as scaffolding modules.

    • Ludger Johannes
    • Robert G. Parton
    • Satyajit Mayor
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 16, P: 311-321

  • Many endocytic uptake events depend on the ‘pinchase’ activity of dynamin. By measuring the orientation of single gold nanorods, a new study reveals that invaginated clathrin-coated endocytic pits undergo a strong rotational twist prior to or concomitant with their detachment.

    • Ludger Johannes
    • Cesar Augusto Valades-Cruz
    News & Views
    Nature Cell Biology
    Volume: 23, P: 812-813

  • Endophilin-A2 (endoA2) is shown to mediate clathrin-independent endocytosis of Shiga and cholera toxins, and to function in parallel with dynamin and actin in the pulling-force-driven scission of Shiga-toxin-induced tubular structures.

    • Henri-François Renard
    • Mijo Simunovic
    • Ludger Johannes
    Research
    Nature
    Volume: 517, P: 493-496

  • Ivashenka et al. report that galectin-3 (Gal3) binding to lactotransferrin drives its transcytosis in enterocytes. Such trafficking is Gal3- and glycosphingolipid-dependent, and Gal3 is found in clathrin-independent carriers. These findings suggest that polarized trafficking across the intestinal barrier relies on this glycolipid and lectin (GL-Lect)-mediated endocytosis.

    • Alena Ivashenka
    • Christian Wunder
    • Massiullah Shafaq-Zadah
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-15