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Showing 1–8 of 8 results
Advanced filters: Author: "Lukas Sommer" Clear advanced filters

  • The transcription factor Yin Yang 1 (YY1) plays an important role in human disease, yet little is known about its role in brain development. This study shows that YY1 controls cerebral cortex development by maintaining proliferation and survival of neural progenitor cells via transcriptional regulation of genes involved in metabolism and protein translation.

    • Luis Zurkirchen
    • Sandra Varum
    • Lukas Sommer
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-16

  • Melanoma cells can switch between proliferative and invasive phenotypes. Here the authors show that the embryonic stem cell factor Sall4 is a negative regulator of melanoma phenotype switching where its loss leads to the acquisition of an invasive phenotype, due to derepression of invasiveness genes.

    • Johanna Diener
    • Arianna Baggiolini
    • Lukas Sommer
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • The epigenetic modifier EZH2 is highly expressed in melanoma but its role in cancer initiation and progression is still unclear. Here the authors use mouse models and human cell lines to show that EZH2 has an essential role in melanoma progression and metastasis, thus highlighting its potential as a therapeutic target.

    • Daniel Zingg
    • Julien Debbache
    • Lukas Sommer
    Research
    Nature Communications
    Volume: 6, P: 1-17

  • The peripheral nervous system has been implicated in wound healing. Here, Parfejevs and colleagues report that cutaneous wounding in mice induces the de-differentiation and proliferation of Schwann cells, which disseminate into the wound bed, secrete soluble factors, and promote wound healing.

    • Vadims Parfejevs
    • Julien Debbache
    • Lukas Sommer
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16

  • The aggressive nature of melanoma cells relies on their ability to switch from a high-proliferative/low-invasive to a low-proliferative/high-invasive state; however, the mechanisms governing this switch are unclear. Here, using in vivo models of human melanoma, the authors show that CD271 is a key regulator of phenotype switching and metastasis formation.

    • Gaetana Restivo
    • Johanna Diener
    • Lukas Sommer
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-16

  • Shakhova, Sommer and colleagues use mouse models to demonstrate that the Sox10 transcription factor is crucial for the formation and maintenance of giant congenital naevi and melanoma. They show, in human melanoma cells, that Sox10 promotes neural crest stem cell properties, cell proliferation and cell survival.

    • Olga Shakhova
    • Daniel Zingg
    • Lukas Sommer
    Research
    Nature Cell Biology
    Volume: 14, P: 882-890