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Showing 1–10 of 10 results
Advanced filters: Author: "Luke A J O'Neill" Clear advanced filters

  • The Science Gallery, Trinity College Dublin, recently held an exhibition called “INFECTIOUS: STAY AWAY” that used art to illustrate infection and immunity. Luke O'Neill talks to one of the artists, Gordana Novakovic, about her involvement in this project.

    • Luke A J O'Neill
    • Cliona O'Farrelly
    Comments & Opinion
    Nature Immunology
    Volume: 10, P: 1043-1045

  • The chirality, or handedness, of nanoparticles is shown to be a key factor in determining how well such particles engage with the immune system — a finding that might help to inform the design of vaccines and anticancer therapeutics.

    • Alexander Hooftman
    • Luke A. J. O’Neill
    News & Views
    Nature
    Volume: 601, P: 323-325

  • Induction of the microRNA miR-182 by interleukin 2 in helper T lymphocytes targets the transcription factor Foxo1 and promotes clonal expansion. Targeting this process opens new possibilities for adjuvancy, immunosuppression and anti-inflammatory therapeutics.

    • Luke A J O'Neill
    News & Views
    Nature Immunology
    Volume: 11, P: 983-984

  • The activation of dendritic cells by Toll-like receptors leads to a rapid enhancement in glycolysis. Glucose is metabolized to pyruvate and from there to citrate in the mitochondria, which leads ultimately to membrane biosynthesis in the endoplasmic reticulum and Golgi to support the activation of dendritic cells.

    • Luke A J O'Neill
    News & Views
    Nature Immunology
    Volume: 15, P: 314-315

  • Researchers gathered at the Wellcome Trust Genome Campus in Hinxton, Cambridge, for the first Innate Immune Memory Conference dedicated to the adaptive characteristics of innate immunity, to further the understanding of this newly described immunological process that probably has a central role in host defense and inflammation.

    • Mihai G Netea
    • Eicke Latz
    • Luke A J O'Neill
    News & Views
    Nature Immunology
    Volume: 16, P: 675-679

  • A strain of Escherichia coli that causes urinary tract infections seems to take hold in the body by interfering with signaling through Toll-like receptors (TLRs). The mechanism involves a secreted bacterial protein that is taken up by cells and clogs up the TLR signaling mechanism (pages 399–406).

    • Luke A J O'Neill
    News & Views
    Nature Medicine
    Volume: 14, P: 370-372

  • Toll-like receptor signaling induces the production of proinflammatory cytokines and type I interferons. Inhibition of the kinase IRAK1 by the phosphatase SHP-1 provides reciprocal regulation of these pathways by dampening the former while enhancing the latter.

    • Luke A J O'Neill
    News & Views
    Nature Immunology
    Volume: 9, P: 459-461

  • The high levels of tissue-damaging reactive oxygen species that arise during a stroke or heart attack have been shown to be generated through the accumulation of the metabolic intermediate succinate. See Letter p.431

    • Luke A. J. O'Neill
    News & Views
    Nature
    Volume: 515, P: 350-351

  • The past 15 years have seen a breakthrough in the field of innate immunity. In this Timeline article, the authors discuss the early events that led to the identification of Toll-like receptors as the prototype pattern-recognition receptors that link innate and adaptive immune responses.

    • Luke A. J. O'Neill
    • Douglas Golenbock
    • Andrew G. Bowie
    Reviews
    Nature Reviews Immunology
    Volume: 13, P: 453-460

  • In this Review, the authors provide a comprehensive overview of the role of macrophage dynamics in determining the initiation, progression and regression of atherosclerotic inflammation. Understanding the factors that determine the inflammatory state of the plaque may help to identify potential therapeutic targets for plaque regression.

    • Kathryn J. Moore
    • Frederick J. Sheedy
    • Edward A. Fisher
    Reviews
    Nature Reviews Immunology
    Volume: 13, P: 709-721