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Showing 1–12 of 12 results
Advanced filters: Author: "Lynda Chin" Clear advanced filters

  • A panel of experts discusses the challenge of translating findings from current mouse models to the clinic.

    • Lynda Chin
    • Frederic de Sauvage
    • William Weiss
    Special Features
    Nature Biotechnology
    Volume: 31, P: 392-395

  • Genomic genetically engineered mouse models (GEMMs) have provided a wealth of information about the genes and factors involved in tumour progression. However, various limitations exist for such models, particularly for preclinical drug development. So, what improvements can the non-germline GEMMs offer?

    • Joerg Heyer
    • Lawrence N. Kwong
    • Lynda Chin
    Reviews
    Nature Reviews Cancer
    Volume: 10, P: 470-480

  • A genome-wide screen has identified a frequent region of amplification on chromosome 5p13 in a number of cancer types. Functional studies now identify a protein localized to the Golgi apparatus, GOLPH3, as a novel oncogene affected by this amplification which can transform cells in vitro and lead to tumour formation in vivo. GOLPH3 overexpression activates the mTOR signalling pathway and renders cancer cells sensitive to the drug rapamycin.

    • Kenneth L. Scott
    • Omar Kabbarah
    • Lynda Chin
    Research
    Nature
    Volume: 459, P: 1085-1090

  • Next-generation sequencing has allowed an unprecedented genomic characterization of diverse cancer types. This Review describes our latest understanding of cancer genomes, including methods to interpret the mutation data, and the emerging biological and clinical implications.

    • Ian R. Watson
    • Koichi Takahashi
    • Lynda Chin
    Reviews
    Nature Reviews Genetics
    Volume: 14, P: 703-718

  • With a comprehensive analysis of sequencing data, DNA copy number, gene expression and DNA methylation in a large number of human glioblastomas, The Cancer Genome Atlas project initiative provides a broad overview of the genes and pathways that are altered in this cancer type.

    • Roger McLendon
    • Allan Friedman
    • Elizabeth Thomson
    Research
    Nature
    Volume: 455, P: 1061-1068

  • Orienting cancer drug discovery to the patient requires relating the genetic features of tumors to acquired gene and pathway dependencies and identifying small-molecule therapeutics that target them.

    • Stuart L Schreiber
    • Alykhan F Shamji
    • Bruce A Posner
    Comments & Opinion
    Nature Biotechnology
    Volume: 28, P: 904-906

  • In a mouse model of prostate cancer it is found that that the TGF-β signalling pathway limits tumour progression and metastasis. Using markers of this pathway and other biologically relevant factors, a four-gene signature is identified that is associated with poorer clinical outcome and metastatic progression in several prostate cancer cohorts, especially in combination with other clinical parameters. This signature may prove useful for the development of a better prognostic test for those cases of prostate cancer in which deciding on the right treatment regime while avoiding over-treatment constitutes an important clinical challenge.

    • Zhihu Ding
    • Chang-Jiun Wu
    • Ronald A. DePinho
    Research
    Nature
    Volume: 470, P: 269-273