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Showing 1–5 of 5 results
Advanced filters: Author: "M Bradley" Clear advanced filters

  • Cell engineering using polymeric material is an area that remains largely unexplored. This protocol describes two light-driven approaches for synthesizing bioactive polymers within intricate intracellular settings.

    • Mohamed Abdelrahim
    • Quan Gao
    • Jin Geng
    Protocols
    Nature Protocols
    P: 1-42

  • Killer whales have evolved into specialized ecotypes based on hunting strategies and ecological niches. Here, Andrew Foote and colleagues sequenced the whole genome of individual killer whales representing 5 different ecotypes from North Pacific and Antarctic, and show expansion of small founder groups to adapt to specific ecological niches.

    • Andrew D. Foote
    • Nagarjun Vijay
    • Jochen B.W. Wolf
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • In a study conducted in selected US hospitals, bypassing the emergency department with direct transport to the cardiac catheterization laboratory resulted in a reduced time to reperfusion for patients with ST-segment elevation myocardial infarction. However, this strategy was used infrequently—mostly during working hours—and varied significantly between hospitals.

    • Charles Maynard
    • Steven M. Bradley
    News & Views
    Nature Reviews Cardiology
    Volume: 10, P: 491-492

  • Cathepsin D (CatD) is an aspartic acid protease involved in the immune response of macrophages to bacterial infection, and the development of pH insensitive CatD probes is vital in order to detect its activity across multiple cellular components. Here, the authors develop a water soluble and pH insensitive FRET-based fluorescent probe for the sensitive detection of CatD.

    • Maria Rodriguez-Rios
    • Brian J. McHugh
    • Mark Bradley
    ResearchOpen Access
    Communications Chemistry
    Volume: 6, P: 1-8

  • Recent advances in areas such as natural product biosynthesis, synthetic biology and the development of biosensors are providing new opportunities to directly harness evolutionary pressure to identify and optimize compounds with desired bioactivities. This article describes innovations in the key components of such strategies, highlights pioneering examples that indicate their potential, and discusses the scientific gaps and challenges that remain to be addressed to realize this potential more broadly in drug discovery.

    • Andrew M. Davis
    • Alleyn T. Plowright
    • Eric Valeur
    Reviews
    Nature Reviews Drug Discovery
    Volume: 16, P: 681-698