Arterial calcification and metabolic bone disease increasingly afflict our aging, dysmetabolic population. Clinical and translational research efforts have converged to highlight that arterial calcification is actively regulated by osteotropic signals that control skeletal physiology and development. This Review discusses the emerging role of bone-vascular interactions in mineral metabolism and the endocrine regulation of arteriosclerotic disease.
- Bithika Thompson
- Dwight A. Towler