Environmental endocrine disrupting chemicals (EDCs) perturb reproductive development and function. Recent evidence suggests that developmental EDC exposures may disrupt the sexual differentiation of reproductive neuroendocrine systems through epigenetic programming of hypothalamic gene expression. This Review discusses endocrine disruption by four prototypical EDCs: vinclozolin, diethylstilbesterol, bisphenol A and polychlorinated biphenyls, and presents evidence for epigenetic modifications and transgenerational transmission of endocrine disrupted traits to future generations.
- Deena M. Walker
- Andrea C. Gore