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Showing 1–11 of 11 results
Advanced filters: Author: "M White" Clear advanced filters

  • The microenvironment of virus-infected cells and uninfected adjacent cells influences infection. Human cytomegalovirus dampens the immune response of neighbouring uninfected cells, but distant cells can mount an antiviral defence.

    • Timothy M. White
    • Felicia D. Goodrum
    News & Views
    Nature
    Volume: 619, P: 39-40

  • The search for therapeutics to treat infections by ebolaviruses and Marburg virus has focused on identifying compounds that interfere with viral entry into host cells. Here, White and Schornberg discuss recent studies that have identified Niemann–Pick C1 (NPC1), a protein that resides deep in the endocytic pathway, as an important host factor in this process.

    • Judith M. White
    • Kathryn L. Schornberg
    Reviews
    Nature Reviews Microbiology
    Volume: 10, P: 317-322

  • The results from two large, prospective, randomized, controlled trials examining the role of 5-α reductase inhibitors in the prevention of prostate cancer have been published. Initial results from the Prostate Cancer Prevention Trial (PCPT) were met with both enthusiasm and skepticism. The recently published REDUCE trial seems to corroborate the findings of the PCPT and reinforce the chemopreventive potential of 5-α reductase inhibitors. This article will assess the REDUCE trial and place the results of the 5-α reductase inhibitor trials in the context of clinical practice.

    • Wesley M. White
    • Edward D. Kim
    News & Views
    Nature Reviews Clinical Oncology
    Volume: 7, P: 487-488

  • Cellular targets of kinase inhibitors are identified by mass spectrometric analysis of binding to “kinobeads.”

    • Forest M White
    News & Views
    Nature Biotechnology
    Volume: 25, P: 994-996

  • An analysis of geochemical data reveals a substantial change in the composition of Earth's magmas about 2.5 billion years ago, just as Earth's atmosphere and climate were also changing drastically. See Letter p.490

    • William M. White
    News & Views
    Nature
    Volume: 485, P: 452-453

  • Emerging data indicate that exercise modulates cancer biology and disease outcomes; however, the molecular mechanisms are poorly established. In this Opinion article, the authors speculate on how exercise might reprogramme the tumour microenvironment to influence cancer hallmarks.

    • Graeme J. Koelwyn
    • Daniela F. Quail
    • Lee W. Jones
    Reviews
    Nature Reviews Cancer
    Volume: 17, P: 620-632

  • A few modest adjustments to the planning and delivery of talks can help scientists share ideas with their peers more effectively, say Scott St. George and Michael White.

    • Scott St. George
    • Michael White
    Comments & Opinion
    Nature
    Volume: 579, P: 621-622