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Showing 1–3 of 3 results
Advanced filters: Author: "M. Frank" Clear advanced filters

  • The complement system has long been known to have a pathogenic role in various disorders, but the therapeutic potential of modulating complement responses has only recently been recognized. In this article, Wagner and Frank review those diseases associated with complement activation and deregulation and focus on promising therapeutic strategies and agents that are currently in the clinic.

    • Eric Wagner
    • Michael M. Frank
    Reviews
    Nature Reviews Drug Discovery
    Volume: 9, P: 43-56

  • The discoverer of free PSA and his colleagues assess the clinical utility of this most widely used disease biomarker. The article encompasses recently published data from randomized screening trials, and the potential of PSA density, dynamics and subforms to enhance the predictive capacity of total PSA. The PSA characteristics of BPH, prostatitis and prostate cancer are summarized, and the effects of age and obesity presented.

    • David Ulmert
    • M. Frank O'Brien
    • Hans Lilja
    Reviews
    Nature Reviews Urology
    Volume: 6, P: 384-391

  • There is a paucity of phase III data comparing chemoradiation with radiation alone for treating invasive bladder cancer; however, an ongoing Australian trial is attempting to address this lack of data. Strategies that combine systemic chemotherapy and radiotherapy have been explored and have yielded better local control than either modality alone. The role of systemic chemotherapy and the controversies surrounding the use of radical surgery versus chemoradiation are discussed.

    • Toni K Choueiri
    • Derek Raghavan
    Reviews
    Nature Clinical Practice Oncology
    Volume: 5, P: 444-454