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Showing 1–6 of 6 results
Advanced filters: Author: "M. Ikeda" Clear advanced filters

  • A reduction-responsive oligonucleotide was successfully constructed by post-modification of an oligonucleotide with a diazo compound bearing a 4-nitrobenzyl group as a reduction-responsive cleavable moiety. High-performance liquid chromatography and mass spectrometry were used to reveal the introduction of the 4-nitrobenzyl group to the 5′-phosphate group of the oligonucleotide, and the subsequent reduction-triggered recovery of the original oligonucleotide. The protocol used for the preparation of this reduction-responsive oligonucleotide is simple and it will have various applications in the fields of chemical and synthetic biology.

    • Nanami Shirakami
    • Sayuri L. Higashi
    • Masato Ikeda
    ResearchOpen Access
    Polymer Journal
    Volume: 53, P: 741-746

  • This article describes the self-assembly of Fmoc-dipeptides comprising α-methyl-L-phenylalanine. The position and number of methyl groups introduced onto the α carbons of the Fmoc-dipeptides as α-methyl-L-phenylalanine have a marked influence on the morphology of supramolecular nanostructures and the hydrogel formation ability.

    • Hanae Arakawa
    • Kumi Takeda
    • Masato Ikeda
    ResearchOpen Access
    Polymer Journal
    Volume: 52, P: 923-930

  • This focus review describes that modular and hybrid molecular design approach used to introduce artificial chemical reactive groups into biomolecules or bio-related molecules enable the semi-rational construction of stimuli-responsive supramolecular systems.

    • Masato Ikeda
    Reviews
    Polymer Journal
    Volume: 51, P: 371-380

  • In this review, we overview the recent advances associated with seminal findings in the development of nucleic acid-based fluorescent sensor systems aimed at application for exploring intracellular phenomena. We described the fluorescence signal generation mechanisms of each nucleic acid-based fluorescent sensor, including molecular beacon and quencher-free linear probes, as well as aptamer or DNAzyme-based systems. In addition, cascade hybridization chain reaction and catalyzed hairpin assembly are introduced as methods for amplifying fluorescence signals under isothermal conditions.

    • Aya Shibata
    • Sayuri L. Higashi
    • Masato Ikeda
    Reviews
    Polymer Journal
    Volume: 54, P: 751-766