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Showing 1–6 of 6 results
Advanced filters: Author: "M. RICE" Clear advanced filters

  • Hepatitis C virus puts about 130 million people worldwide at risk for severe liver disease, but no vaccine or broadly effective therapy yet exists. A new study identifies receptor tyrosine kinases as host factors required for hepatitis C virus entry—potentially opening the door for new antiviral strategies (pages 589–595).

    • Gisa Gerold
    • Charles M Rice
    News & Views
    Nature Medicine
    Volume: 17, P: 542-544

  • Hepatitis C virus (HCV) afflicts more than 170 million people worldwide causing chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. The recent development of complete cell-culture systems for HCV has accelerated the pace of hepatitis research. Specifically, these techniques have provided new insights into the virus lifecycle that are reviewed here. This should pave the way for developing bespoke and effective antiviral therapies and vaccines.

    • Darius Moradpour
    • François Penin
    • Charles M. Rice
    Reviews
    Nature Reviews Microbiology
    Volume: 5, P: 453-463

  • A stampede of recent clinical studies suggests that we are on the cusp of developing well-tolerated, orally delivered drugs that can effectively eradicate hepatitis C virus from most, if not all, infected individuals.

    • Charles M. Rice
    • Mohsan Saeed
    News & Views
    Nature
    Volume: 510, P: 43-44

  • Infection with hepatitis C is one of the main causes of liver disease, yet there are no broadly effective treatments. Discovery of a potent inhibitor of this virus shows that researchers must think outside the box.

    • Catherine L. Murray
    • Charles M. Rice
    News & Views
    Nature
    Volume: 465, P: 43-44

  • Hepatitis C virus (HCV) is a positive-strand RNA virus that causes significant pathology in humans. Here, Lindenbach and Rice discuss recent insights into the unique properties of HCV particles and then review HCV entry and assembly, with a focus on the viral and host factors involved.

    • Brett D. Lindenbach
    • Charles M. Rice
    Reviews
    Nature Reviews Microbiology
    Volume: 11, P: 688-700