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Showing 1–5 of 5 results
Advanced filters: Author: "M. Schwartz" Clear advanced filters
  • Janus kinases (JAKs) are essential signalling mediators downstream of many pro-inflammatory cytokines. Jakinibs — small-molecule inhibitors of JAKs — have gained traction as safe and efficacious options for the treatment of inflammation-driven pathologies. This Review discusses the biology, development and efficacy of jakinibs in the treatment of immune and inflammatory diseases.

    • Daniella M. Schwartz
    • Yuka Kanno
    • John J. O'Shea
    Reviews
    Nature Reviews Drug Discovery
    Volume: 16, P: 843-862
  • Hepatocellular carcinoma (HCC) generally develops as a consequence of underlying liver disease, most commonly viral hepatitis. Currently, surgery remains the treatment of choice for HCC; however, due to underlying liver disease only a minority of those affected are candidates for resection, and access to transplantation is limited by organ availability. The authors of this review discuss when liver resection, nonsurgical HCC treatment and management before liver transplantation should be considered, and the applications of nonsystemic therapies.

    • Myron Schwartz
    • Sasan Roayaie
    • Manousos Konstadoulakis
    Reviews
    Nature Clinical Practice Oncology
    Volume: 4, P: 424-432