To maintain chromosome superstructure and integrity, topoisomerases resolve specific DNA superstructures or intermediates that arise from processes such as DNA repair, transcription and replication, and chromosome compaction. Despite decades of study, new insights into the cellular function and regulation of topoisomerases, as well as their use as therapeutic targets, continue to emerge.
- Seychelle M. Vos
- Elsa M. Tretter
- James M. Berger