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Showing 1–3 of 3 results
Advanced filters: Author: "M. van der Flier" Clear advanced filters

  • The progression of Alzheimer disease might be monitored by measuring the rate of hippocampal volume loss by means of MRI. Research suggests that a reduction in hippocampal volume can be detected over a period as short as 6 months, and that such volume loss is associated with cognitive decline and other indicators of Alzheimer disease neuropathology.

    • Wiesje M. van der Flier
    • Philip Scheltens
    News & Views
    Nature Reviews Neurology
    Volume: 5, P: 361-362

  • Suspected non-Alzheimer disease pathophysiology (SNAP) is a biomarker-based concept that applies to individuals with normal levels of amyloid-β biomarkers in the brain, but in whom biomarkers of neurodegeneration are abnormal. Clinically normal and mildly impaired individuals with SNAP are at increased risk of poor clinical and cognitive outcomes. In this Perspectives article, Clifford Jack and colleagues describe the available data on SNAP and address topical controversies in the field.

    • Clifford R. Jack Jr
    • David S. Knopman
    • Stephanie J. B. Vos
    Reviews
    Nature Reviews Neurology
    Volume: 12, P: 117-124