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Advanced filters: Author: "Malcolm A S Moore" Clear advanced filters

  • Two anatomical niches for hematopoietic stem cells (HSCs) have been reported in the bone marrow, but a distinct function for each of these niches has remained unclear. A new role in stem cell proliferation has now been identified for the adhesion molecule E-selectin expressed by bone marrow endothelial cells at the vascular niche (pages 1651–1657).

    • Malcolm A S Moore
    News & Views
    Nature Medicine
    Volume: 18, P: 1613-1614

  • Recent studies show that Musashi-2 (MSI2), a molecule that binds RNA, increases proliferation of normal and malignant blood stem cells. In humans, increased amounts of MSI2 correlate with poor prognosis of leukemia—indicating that MSI2 may be a target to treat this type of cancer.

    • Malcolm A S Moore
    News & Views
    Nature Medicine
    Volume: 16, P: 963-965