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Showing 1–2 of 2 results
Advanced filters: Author: "Malte Gersch" Clear advanced filters

  • A probe for the ubiquitin-like protein Fubi led to the discovery of dual ubiquitin/Fubi C-terminal hydrolase activity in the deubiquitinase USP16 in addition to USP36, enabling structural characterization of this distinctive Ub/Ubl specificity, and revealed a synergistic role of USP16 in ribosomal protein maturation.

    • Rachel O’Dea
    • Nafizul Kazi
    • Malte Gersch
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 19, P: 1394-1405

  • The deubiquitinase UCHL1 has been linked to cancer invasiveness and neurodegeneration yet its molecular roles have remained poorly defined. Here the authors reveal the structural basis for how UCHL1 can be specifically inhibited and how chemogenomic probes can be used to dissect its functions in living cells.

    • Christian Grethe
    • Mirko Schmidt
    • Malte Gersch
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17