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Showing 1–3 of 3 results
Advanced filters: Author: "Manuel A Friese" Clear advanced filters

  • Great progress has been made in elucidating the acute inflammatory components of multiple sclerosis (MS), but the pathophysiological mechanisms of the concomitant neurodegeneration are poorly understood. Friese and colleagues review the current state of knowledge regarding the pathological mechanisms of neuroaxonal dysfunction and injury in MS, highlighting evidence that axonal and neuronal impairment are early and independent contributors to disease progression.

    • Manuel A. Friese
    • Benjamin Schattling
    • Lars Fugger
    Reviews
    Nature Reviews Neurology
    Volume: 10, P: 225-238

  • This Review provides an insightful discussion on the current concepts in multiple sclerosis research, including genetic predisposition and environmental triggers, and explores the evolving link between inflammation and neurodegeneration. The authors highlight the clinical challenges and key questions that remain to be addressed.

    • Calliope A. Dendrou
    • Lars Fugger
    • Manuel A. Friese
    Reviews
    Nature Reviews Immunology
    Volume: 15, P: 545-558

  • With recent studies revealing the genetic determinants of multiple sclerosis, our attention must now turn to defining the function of the candidate genes in disease pathogenesis. This Review describes our progress so far and the approaches required to tease out the contribution made by multiple genetic and environmental factors.

    • Lars Fugger
    • Manuel A. Friese
    • John I. Bell
    Reviews
    Nature Reviews Immunology
    Volume: 9, P: 408-417