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Showing 1–11 of 11 results
Advanced filters: Author: "Manuel Serrano" Clear advanced filters

  • The function of the deacetylase SIRT1 in cancer is complex and controversial. This article discusses the recent progress that has been made in mouse models to address the role of SIRT1 in tumour development.

    • Daniel Herranz
    • Manuel Serrano
    Reviews
    Nature Reviews Cancer
    Volume: 10, P: 819-823

  • Oncogene-induced senescence was first seen in cultured cells. However, since the initialin vitro observation of this phenomenon, it has been shown to occur in both mouse and human tumours. What do we know about tumour cell senescence in vivo, and how might this be exploited therapeutically?

    • Manuel Collado
    • Manuel Serrano
    Reviews
    Nature Reviews Cancer
    Volume: 10, P: 51-57

  • Convergent mechanisms limit the amount of cellular damage and thereby protect against both cancer and ageing, whereas divergent mechanisms prevent excessive proliferation and, therefore, prevent cancer but promote ageing. The net balance between these mechanisms ensures a healthy, cancer-free lifespan until late adulthood in most individuals.

    • Manuel Serrano
    • Maria A. Blasco
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 8, P: 715-722

  • In vivo reprogramming of somatic cells is hampered by the need for vectors to express the OKSM factors in selected organs. Here the authors report new AAV-based vectors capable of in vivo reprogramming at low doses.

    • Elena Senís
    • Lluc Mosteiro
    • Dirk Grimm
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • The recent finding that the induction of cellular senescence is associated with the premalignant stages of tumour progression indicates that markers of senescence might prove to be useful diagnostic and prognostic tools. This article presents some of the more promising candidates.

    • Manuel Collado
    • Manuel Serrano
    Reviews
    Nature Reviews Cancer
    Volume: 6, P: 472-476

  • Cellular senescence is a physiological mechanism for thwarting the proliferation of tumour cells. Encouraging cancer-prone cells to senesce might therefore be a way to nip this disease in the bud.

    • Manuel Serrano
    News & Views
    Nature
    Volume: 464, P: 363-364

  • Damaged cells can initiate cancer. To avert this, faulty cells disable their own propagation by undergoing senescence. But for full protection against liver cancer, the senescent cells must be cleared by the immune system. See Letter p.547

    • Manuel Serrano
    News & Views
    Nature
    Volume: 479, P: 481-482

  • Classically associated with ageing and cancer, cellular senescence also seems to function in tissue remodelling during embryonic development and tissue repair, in which senescent cells are cleared before regeneration. Senescence is therapeutically relevant, as it can be either beneficial or detrimental in different diseases.

    • Daniel Muñoz-Espín
    • Manuel Serrano
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 15, P: 482-496

  • Senescence is a state of permanent cell cycle arrest. This Review highlights the chemical characteristics of senescence and how we can use small molecules to target, detect or eliminate senescent cells, as well as to induce or inhibit senescence.

    • Beatriz Lozano-Torres
    • Alejandra Estepa-Fernández
    • Félix Sancenón
    Reviews
    Nature Reviews Chemistry
    Volume: 3, P: 426-441